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For the prediction to be reliable, the patient must meet the following conditions:

Have a diagnosis of class 1 (symmetrical) autosomal dominant polycystic kidney disease (ADPKD), with or without confirmation through genetic testing or family history.
Be between 18 and 79 years of age.
Preserve both kidneys, with no significant differences in size between them.
Have no history of kidney tumors or kidney resections.
Have no diagnosis or suspicion of concomitant nephropathy, such as diabetic nephropathy, glomerulonephritis, CAKUT nephropathy, or other kidney conditions.
Have a stable kidney function, ideally assessed in the outpatient setting.
Not have any condition that affects the accuracy of creatinine as a marker of GFR, such as extremes in muscle mass or the intake of certain drugs.

Kidney size must be measured on CT or MRI. It is recommended that the age and serum creatinine values used for the estimation are obtained within ±6 months of the imaging study. Follow the instructions below to correctly perform measurements:

Kidney height

Measure the height along the coronal axis using a line parallel to the kidney's longitudinal axis at the point of greatest measurement. Ensure the line traces the edge of the renal parenchyma, excluding the outline of any protruding cysts

Kidney depth

Measure the depth along the axial axis using a line perpendicular to the renal hilum at the point of greatest measurement. Ensure the line traces the edge of the renal parenchyma, excluding the outline of any protruding cysts

Kidney width

Measure the width along the axial axis using a line at 90° to the depth measurement line, positioned at the level of the renal hilum. Extend the measurement to an imaginary line that continues the renal border at the level of the hilum (dashed blue line). Ensure the line traces the edge of the renal parenchyma, excluding the outline of any protruding cysts

ADPKD Lifetime ESKD Risk Calculator

How to use